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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TOP2A
All Species:
47.58
Human Site:
S654
Identified Species:
74.76
UniProt:
P11388
Number Species:
14
Phosphosite Substitution
Charge Score:
0.14
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P11388
NP_001058.2
1531
174385
S654
A
A
I
S
L
A
F
S
K
K
Q
I
D
D
R
Chimpanzee
Pan troglodytes
XP_516332
1634
184611
S683
A
A
I
T
L
A
F
S
K
K
K
I
D
D
R
Rhesus Macaque
Macaca mulatta
XP_001092092
1620
182490
S669
A
A
I
T
L
A
F
S
K
K
K
I
D
D
R
Dog
Lupus familis
XP_537646
1532
174610
S654
A
A
I
S
L
A
F
S
K
K
Q
I
D
D
R
Cat
Felis silvestris
Mouse
Mus musculus
Q01320
1528
172859
S653
A
A
I
S
L
A
F
S
K
K
Q
V
D
D
R
Rat
Rattus norvegicus
P41516
1526
173202
S652
A
A
I
S
L
A
F
S
K
K
Q
V
D
D
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001519680
1746
195650
S682
A
A
I
S
L
A
F
S
K
K
Q
I
D
D
R
Chicken
Gallus gallus
O42130
1553
174974
S655
A
A
I
T
L
A
F
S
K
K
K
V
E
E
R
Frog
Xenopus laevis
NP_001082502
1579
178601
S652
A
A
I
T
M
A
F
S
R
K
K
V
D
D
R
Zebra Danio
Brachydanio rerio
NP_001003834
1574
177254
S653
E
A
I
T
L
A
F
S
K
K
M
I
E
E
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P15348
1447
164377
S634
E
S
I
V
M
A
F
S
K
K
H
I
E
S
R
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q23670
1520
172316
S689
N
A
V
D
M
A
F
S
K
K
K
I
E
E
R
Sea Urchin
Strong. purpuratus
XP_783546
1448
163750
I662
T
D
M
E
R
H
R
I
P
F
E
Y
T
G
P
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P30182
1473
164089
D646
F
V
W
E
D
E
Q
D
G
E
A
I
E
L
A
Baker's Yeast
Sacchar. cerevisiae
P06786
1428
164196
D634
F
H
S
L
Q
G
N
D
K
D
Y
I
D
L
A
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
67.2
67.5
93.6
N.A.
89
88.7
N.A.
71.3
76.3
70.7
67.9
N.A.
51.2
N.A.
53
58.9
Protein Similarity:
100
78.6
78.4
96.4
N.A.
93.6
93.2
N.A.
79.1
85
81.8
78.8
N.A.
66.8
N.A.
70.4
73.4
P-Site Identity:
100
86.6
86.6
100
N.A.
93.3
93.3
N.A.
100
66.6
66.6
66.6
N.A.
53.3
N.A.
53.3
0
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
100
100
100
86.6
N.A.
73.3
N.A.
86.6
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
45
42.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
61.4
60.4
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
20
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
60
74
0
0
0
80
0
0
0
0
7
0
0
0
14
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
7
0
7
7
0
0
14
0
7
0
0
60
54
0
% D
% Glu:
14
0
0
14
0
7
0
0
0
7
7
0
34
20
0
% E
% Phe:
14
0
0
0
0
0
80
0
0
7
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
7
0
0
7
0
0
0
0
7
0
% G
% His:
0
7
0
0
0
7
0
0
0
0
7
0
0
0
0
% H
% Ile:
0
0
74
0
0
0
0
7
0
0
0
67
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
80
80
34
0
0
0
0
% K
% Leu:
0
0
0
7
60
0
0
0
0
0
0
0
0
14
0
% L
% Met:
0
0
7
0
20
0
0
0
0
0
7
0
0
0
0
% M
% Asn:
7
0
0
0
0
0
7
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
7
0
0
0
0
0
7
% P
% Gln:
0
0
0
0
7
0
7
0
0
0
34
0
0
0
0
% Q
% Arg:
0
0
0
0
7
0
7
0
7
0
0
0
0
0
80
% R
% Ser:
0
7
7
34
0
0
0
80
0
0
0
0
0
7
0
% S
% Thr:
7
0
0
34
0
0
0
0
0
0
0
0
7
0
0
% T
% Val:
0
7
7
7
0
0
0
0
0
0
0
27
0
0
0
% V
% Trp:
0
0
7
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
7
7
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _